Large-enrollment laboratory courses face unique challenges in administration, pedagogy, and assessment. As the number of students approaches or exceeds 100 people, the faculty and staff administrating these labs face similar challenges. This symposium aims to provide a space for the directors of large laboratory courses to share their creative approaches to laboratory curriculum, structure, instruction, and execution of their courses. Discussions of the successful implementation of new ideas, as well as lessons learned from not-so-successful ones, are welcome.