One of the requirements in many health professions programs is one or two semesters of chemistry as a General, Organic, and Biological (GOB) Chemistry course. Teaching the GOB chemistry course has a set of unique challenges for students and instructors. These challenges can be turned into opportunities for novel ideas to be implemented and tested. This symposium will explore the development of relevant GOB curriculum and examine successful classroom practices for the GOB classroom that can be demonstrated to be successful. This may include innovative curriculum modifications/development (both lecture and laboratory), identification of important laboratory skills and exercises to develop these skills, creative/innovative approaches to understanding the concepts of chemistry fundamental to the understanding the science relevant to the students future profession. Presenters are encouraged to share their research, experiences, strategies, and successes with the course. We are especially interested in new curriculum and classroom practices that emerged from COVID. This session will conclude with a discussion among the audience and the presenters to identify successful trends in teaching the GOB course.