Peer-Led Team Learning (PLTL) is a national initiative to promote active learning in STEM classes through the use of peer leaders, students who have successfully completed a course that return to lead students in small groups. The symposium highlights the diverse set of outcomes that have resulted from enacting PLTL or other forms of peer-supported instruction. Additionally, this symposium invites reports of efforts to initiate or sustain PLTL in the chemistry curriculum, to adapt PLTL to online instruction, and to address diversity and equity issues within peer-supported learning. Given the potential for PLTL to have a substantive impact on the experiences of students, peer leaders and/or faculty members, the symposium welcomes presentations that employ any methodological approach.