Large-enrollment lecture (200+ enrolled) courses face unique challenges in administration, pedagogy, assessment and equity. How do faculty adapt their curriculum to try and address all student needs in large and often heterogeneous lecture classes? This symposium aims to provide a space for the instructors of large lecture courses to share their creative approaches to a shifting curriculum, structure, instruction, and execution of their courses. We welcome conversations of both the successful and not-so-successful implementation of new ideas.